“Mass Spectrometric Studies of Neuropeptides in Feeding”

(1R01DK071801)

Active date: 06/01/17-05/31/21

Brief description: This proposal will develop and apply novel MS-based differential peptidomics approach to discover neuropeptides involved in the control and regulation of feeding behavior in Cancer borealis.

“DiLeu-enabled multiplexed quantitation and glycoproteomics for biomarker discovery and validation in Alzheimer’s disease”

(R01 AG052324)

Active date: 1/15/2018-12/31/2022  

Brief description: The major goals of this project are to develop a multi-disciplinary approach to enable identification of biomarkers in Alzheimer’s disease (AD) in cerebrospinal fluids (CSF) collected from patient cohorts at different stages of AD that offer improved sensitivity and specificity for diagnosis and predict dementia onset and progression.

“Combining microseparations and ion mobility mass spectrometry to probe peptidergic signaling in environmental stress”

(CHE-1413596)

Active date: 09/01/17-08/31/20

Brief description: The goal of this proposal is to develop novel ion mobility based MS platform and coupled to microseparations for enhanced peptidome coverage, improved isobaric quantitation of peptides involved in hypoxia stress conditions, D-amino acid containing peptide characterization and gas-phase ion isomer analysis for enhanced peptide identification.

“Multiplex chemical tags for high-throughput glycan and glycopeptide quantitation and characterization”

(1U01CA231081)

Active date: 08/03/2018-07/31/2021

Brief description: This project seeks to address technical challenges in detecting and quantifying diverse native glycan structures and intact glycopeptides by developing a suite of new methods and chemical reagents for high throughput quantifications of complex glycans.

“In Situ Protein Characterization and Visualization in the Mammalian Brain”

(R56 MH110215-01A1)

Active date: 01/01/2017-12/31/2019

Brief description: The main goals of this project are to create next generation of MALDI orbitrap-based mass spectrometry imaging (MSI) technology that enables simultaneous mapping and quantifying in situ protein expression patterns in biological tissues from animal models of diseases and apply this novel platform to autism research.

“National Center for Quantitative Biology of Complex Systems”

(1P41 GM108538-01A1)

Active date: 08/01/2016-07/31/2021

Brief description: The major goal of this project is to develop next-generation protein measurement technologies and to make these methods accessible to the broad community. These essential technologies will be developed in the context of a cadre of Driving Biomedical Projects (DBPs). The DBP diversity ensures that the NCQBCS will fulfill its most critical mission: to empower all biomedical researchers, with their sundry models and samples by advancing and making accessible protein quantification technologies.

"Acquisition of a High-Resolution High Speed MALDI Mass Spectrometer for Biomedical Research at UW-Madison.”

Active date: 2/01/2018-1/31/2019

Brief description: The goal of this proposal is to obtain funding for a high resolution high speed rapifleX MALDI TOF/TOF mass spectrometer to be housed in the UW-Madison Pharmacy MS Facility.

“Defining a Proteomic Signature for Soy-Induced Metabolic Changes in Mice.”

Active date: 7/15/2018-7/14/2023

Brief description: Our goal is to identify nutritional biomarkers of soy consumption. Successful outcomes from these studies will identify altered metabolic phenotypes and define a proteomic signature in mice in response to soy consumption.

Li Research Group

 University of Wisconsin Madison

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